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We see a lot of whey protein on the supermarket shelves these days. The high-protein, low-carb diet trend has been highly profitable for cheese makers and whey processors, who once used the cheese byproduct as fertilizer or in animal feed. With more whey going to the human market, animal feed manufacturers are looking for alternative protein sources that maintain animal health while saving costs.

“Since whey protein is the major milk component that goes into milk replacers, it’s the most expensive nutrient ingredient in the formula. There’s long been a search to find alternatives that the very young calf can tolerate and grow well on without allergy problems or poor digestibility,” says Jim Drackley, dairy nutritionist in the Department of Animal Sciences at the University of Illinois.

In a recent study, Drackley and graduate student Sarah Morrison may have found a near-ideal replacement for whey in calf milk replacers: spray-dried plasma protein, supplemented with amino acids threonine and isoleucine. “In previous studies, we’ve found plasma protein is well tolerated when replacing up to a third or a half of the whey protein in milk replacers. There are some limitations in the amino acid profile relative to the ideal protein, though. We wanted to see if we could improve performance by adding those back,” he explains.

The research team fed milk replacer to preweaned calves from birth to eight weeks. Calves were either fed standard whey-based milk replacer with methionine, or milk replacer with methionine and a portion of the whey replaced with plasma protein (5 or 10 percent). In addition to methionine, half of the plasma protein formulations were also supplemented with threonine and isoleucine.

Over the eight-week study, the calves were evaluated for growth and health status. Overall, calves that were fed plasma protein plus the amino acids did just as well as those that were fed standard milk replacer. Without threonine and isoleucine, however, calves that received the higher level of plasma protein did not perform as well.

The results indicate that plasma protein can be used to replace a large portion of whey in milk replacers as long as the amino acid profile is maintained similar to whey proteins. This is good news for those looking to cut costs on farm. “Plasma protein is more expensive than some other sources like soy proteins, but it can be economical compared to whey,” Drackley says.

The benefits of plasma proteins don’t end there. Drackley points to health improvements in the calves that were fed the plasma diets, including lowered rates of diarrhea. “Plasma proteins contain immunoglobulins that have positive effects on the immune system and antimicrobial effects in the animal. The spray-drying process preserves those so they still have some activity in the digestive tract,” he says.

Drackley points out that alternative nutrient sources in animal feed often get a bad rap as byproducts. Instead, he says, we should celebrate the cow’s ability to recycle products humans can’t eat, turning them into wholesome and nutritious foods we can.

The article, “Amino acid supplementation of calf milk replacers containing plasma protein,” is published in the Journal of Dairy Science. First author Sarah Morrison is a graduate student in the Department of Animal Sciences at U of I. Co-author J. Campbell is from APC Inc. Support for the research was provided by the Illinois Agricultural Experiment Station and APC Inc., in Ankeny, Iowa. Jim Drackley was recently interviewed about milk and byproducts in animal feed by the College of Agricultural, Consumer and Environmental Sciences at U of I.

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